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Headache, agitation, drowsiness, lethargy, metabolic acidosis and hypokalemia occurred after overdosing. At very high doses, coma, lasting 20-24 hours followed by full recovery after 3 to 4 days, may occur.
Treatment is symptomatic and supportive. An attempt should be made to remove undigested Topvex from the gastro-intestinal tract using gastric lavage, induction of emesis or activated charcoal. Hemodialysis has been shown to be an effective means to remove Topvex from the body. The patient should be well hydrated.
